Wnt-C59
Cat. No.：YN450104
CAS No. ：1243243-89-1
规格
价格(RMB)
库存
| 产品名称: | Wnt-C59 |
| CAS No.: | 1243243-89-1 |
| Chemical Name: | 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-benzeneacetamide |
| Synonyms: | C59 |
| 分子量: | 379.45 |
| 分子式: | C₂₅H₂₁N₃O |
| SMILES: | O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Wnt-C59 (C59)是高效可口服的PORCN抑制剂，IC50为 74 pM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gao, X., and Hannoush, R.N.Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupineNat. Chem. Biol.10(10),61-68(2014)
Proffitt, K.D., Madan, B., Ke, Z., et al.Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancerCancer Res.73(2),502-507(2013)
Wend, P., Runke, S., Wend, K., et al.WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancerEMBO Mol. Med.5(2),264-279(2013)
