LGK974
Cat. No.：YN450122
CAS No. ：1243244-14-5
规格
价格(RMB)
库存
| 产品名称: | LGK974 |
| CAS No.: | 1243244-14-5 |
| Chemical Name: | 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide |
| Synonyms: | WNT974 |
| 分子量: | 396.44 |
| 分子式: | C₂₃H₂₀N₆O |
| SMILES: | O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LGK974 (WNT974) 是一种有效的，具有口服活性的特异性Porcupine(PORCN) 抑制剂，IC50为 0.1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gao, X., and Hannoush, R.N.Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupineNat. Chem. Biol.10(10),61-68(2014)
Proffitt, K.D., Madan, B., Ke, Z., et al.Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancerCancer Res.73(2),502-507(2013)
Liu, J., Pan, S., Hsieh, M.H., et al.Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974Proc. Natl. Acad. Sci. USA110(50),20224-20229(2013)
Jiang, X., Hao, H.X., Growney, J.D., et al.Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinomaProc. Natl. Acad. Sci. USA110(31),12649-12654(2013)
Lum, L., and Clevers, H.The unusual case of porcupineScience337,922-923(2012)
