Megestrol acetate
Cat. No.：YN481339
CAS No. ：595-33-5
规格
价格(RMB)
库存
| 产品名称: | Megestrol acetate |
| CAS No.: | 595-33-5 |
| Chemical Name: | 17-(acetyloxy)-6-methyl-pregna-4,6-diene-3,20-dione |
| Synonyms: | 醋酸甲地孕酮 |
| 分子量: | 384.51 |
| 分子式: | C₂₄H₃₂O₄ |
| SMILES: | CC([C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])C=C(C)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Megestrol acetate 是具有口服活性的、合成孕激素。Megestrol acetate 可作为食欲刺激素，用于消瘦综合征如恶病质的研究。Megestrol acetate 可下调细胞核和细胞质雄激素受体 (androgen receptors) 的活性。Megestrol acetate 可用于HIV的研究并下调自噬分解代谢途径。 |
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Østergaard, M.D.The oral progestational and anti-ovulatory properties of megestrol acetate and its therapeutic use in gynaecological disordersJ. Obstet. Gynaecol. Br. Emp.72(1),45-48(1965)
Teulings, F.A., van Glise, H.A., Henkelman, M.S., et al.Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancerCancer Res.40(7),2557-2561(1980)
McCarthy, H.D., Crowder, R.E., Dryden, S., et al.Megestrol acetate stimulates food and water intake in the rat: Effects on regional hypothalamic neuropeptide Y concentrationsEur. J. Pharmacol.265(1-2),99-102(1994)
Costa, A.-M., Spence, K.T., Plata-Salamán, C.R., et al.Residual Ca2+ channel current modulation by megestrol acetate via a G-protein αs-subunit in rat hypothalamic neuronesJ. Physiol.487(Pt 2),291-303(1995)
Mantovani, G., Macciò, A., Esu, S., et al.Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patientsEur. J. Cancer33(4),602-607(1997)
Argilés, J.M., Anguera, A., and Stemmler, B.A new look at an old drug for the treatment of cancer cachexia: Megestrol acetateClin. Nutr.32(3),319-324(2013)
