GSK484 hydrochloride
Cat. No.：YN310013
| 产品名称: | GSK484 hydrochloride |
| CAS No.: | 1652591-81-5 |
| Chemical Name: | [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone, monohydrochloride |
| Synonyms: | GSK484 hydrochloride |
| 分子量: | 510.03 |
| 分子式: | C₂₇H₃₂ClN₅O₃ |
| SMILES: | O=C(N1C[C@H](N)[C@H](O)CC1)C2=CC(OC)=C3C(N=C(C(N4CC5CC5)=CC6=C4C=CC=C6)N3C)=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK484 hydrochloride 是一种有效且可逆的肽酰基精氨酸脱亚氨酶 4 (PAD4) 抑制剂。GSK484 hydrochloride 高亲和力与 PAD4 结合，在不存在钙的情况下IC50为 50 nM。在 2 mM 钙的存在下，IC50为 250 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lewis, H.D., Liddle, J., Coote, J.E., et al.Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formationNat. Chem. Biol.11(3),189-191(2015)
