Cl-amidine hydrochloride
Cat. No.：YN310016
CAS No. ：1373232-26-8
| 产品名称: | Cl-amidine hydrochloride |
| CAS No.: | 1373232-26-8 |
| Chemical Name: | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride |
| Synonyms: | |
| 分子量: | 347.24 |
| 分子式: | C₁₄H₂₀Cl₂N₄O₂ |
| SMILES: | O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cl-amidine hydrochloride 是口服有效的PAD抑制剂，其对 PAD1、PAD3 和 PAD4 的IC50值分别为0.8 μM、 6.2 μM 和 5.9 μM。Cl-amidine hydrochloride 可诱导癌细胞的凋亡。Cl-amidine hydrochloride 可诱导 miR-16，引起细胞周期阻滞。Cl-Amidine hydrochloride 可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Luo, Y., Arita, K., Bhatia, M., et al.Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterizationBiochemistry45(39),11727-11736(2006)
Knuckley, B., Causey, C.P., Jones, J.E., et al.Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3Biochem.49(23),1-28(2010)
Muth, A., Subramanian, V., Beaumont, E., et al.Development of a selective inhibitor of protein arginine deiminase 2.J. Med. Chem.60(7),3198-3211(2017)
Slack, J.L., Causey, C.P., and Thompson, P.R.Protein arginine deiminase 4: A target for an epigenetic cancer therapyCell Mol. Life Sci.68(4),709-720(2011)
Biron, B.M., Chung, C.-S., O'Brien, X.M., et al.Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis modepJ. Innate Immun.9(1),22-32(2017)
Willis, V.C., Gizinski, A.M., Banda, N.K., et al.N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-orninthine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritisJ. Immunol.186(7),4396-4404(2011)
