GSK3179106
Cat. No.：YN440012
CAS No. ：1627856-64-7
规格
价格(RMB)
库存
| 产品名称: | GSK3179106 |
| CAS No.: | 1627856-64-7 |
| Chemical Name: | 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-benzeneacetamide |
| Synonyms: | GSK3179106,GSK-3179106,GSK 3179106 |
| 分子量: | 467.41 |
| 分子式: | C₂₂H₂₁F₄N₃O₄ |
| SMILES: | O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)CC2=CC=C(C(C(OCC)=C3)=CNC3=O)C=C2F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK3179106 是一种具有口服活性的，选择性的RET激酶抑制剂，对人和大鼠 RET 的IC50分别为 0.4 nM 和 0.2 nM。GSK3179106 通过减轻炎症后和应激引起的内脏超敏反应而具有用于肠易激综合征 (IBS) 的潜力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Schenck Eidam, H., Russell, J., Raha, K., et al.Discovery of a first-in-class gut-restricted RET kinase inhibitor as a clinical candidate for the treatment of IBSACS Med. Chem. Lett.9(7),623-628(2018)
