Pralsetinib
Cat. No.：YN440154
CAS No. ：2097132-94-8
规格
价格(RMB)
库存
| 产品名称: | Pralsetinib |
| CAS No.: | 2097132-94-8 |
| Chemical Name: | cis-N-[(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxamide; cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methy |
| Synonyms: | BLU-667 |
| 分子量: | 533.60 |
| 分子式: | C₂₇H₃₂FN₉O₂ |
| SMILES: | O=C([C@@]1(OC)CC[C@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pralsetinib (BLU-667) 是一种高效的选择性RET抑制剂。Pralsetinib (BLU-667) 抑制 WT RET，RET 突变体 V804L，V804M，M918T 和 CCDC6-RET 融合，IC50分别为 0.4、0.3、0.4、0.4、0.4 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Subbiah, V. et al.: Cancer Discovery (2018), 8(7), 836-849
