Selpercatinib
Cat. No.：YN440168
CAS No. ：2152628-33-4
规格
价格(RMB)
库存
| 产品名称: | Selpercatinib |
| CAS No.: | 2152628-33-4 |
| Chemical Name: | 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-pyrazolo[1,5-a]pyridine-3-carbonitrile |
| Synonyms: | LOXO-292 |
| 分子量: | 525.60 |
| 分子式: | C₂₉H₃₁N₇O₃ |
| SMILES: | N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Selpercatinib (LOXO-292) 是一种有效的RET激酶抑制剂，抑制 RET (WT)，RET (V804M) 和 RET (G810R)，IC50分别为 14.0 nM，24.1 nM 和 530.7 nM，详细信息请参考专利文献 WO2018071447A1 中的化合物 Example 163。具有抗肿瘤作用。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Subbiah, V., Velcheti, V., Tuch, B.B., et al.Selective RET kinase inhibition for patients with RET-altered cancersAnn. Oncol.29(8),1869-1876(2018)
