GSK481
Cat. No.：YN270004
CAS No. ：1622849-58-4
| 产品名称: | GSK481 |
| CAS No.: | 1622849-58-4 |
| Chemical Name: | 5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-isoxazolecarboxamide |
| Synonyms: | GSK'481 |
| 分子量: | 377.39 |
| 分子式: | C₂₁H₁₉N₃O₄ |
| SMILES: | O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK481 是一种高效的，选择性的，特异性的RIP1抑制剂，其IC50值为 1.3 nM，可抑制野生型人RIP1中的 Ser166磷酸化 (IC50值为 2.8 nM)。GSK481 对 U937 细胞的IC50值为 10 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Harris, P.A., King, B.W., Bandyopadhyay, D., et al.DNA-encoded library screening identifies benzo[b][1,4]oxazepin-4-ones as highly potent and monoselective receptor interacting protein 1 kinase inhibitorsJ. Med. Chem.59(5),2163-2178(2016)
Geserick, P., Wang, J., Schilling, R., et al.Absence of RIPK3 predicts necroptosis resistance in malignant melanomaCell Death Dis.6,e1884(2015)
