GSK583
Cat. No.：YN270005
| 产品名称: | GSK583 |
| CAS No.: | 1346547-00-9 |
| Chemical Name: | 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
| Synonyms: | GSK583,GSK-583,GSK 583 |
| 分子量: | 398.45 |
| 分子式: | C₂₀H₁₉FN₄O₂S |
| SMILES: | FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK583 是一种高效、口服有效的、高选择性的RIP2 Kinase抑制剂，其IC50值为 5 nM。GSK583 可同时抑制TNF-α 和IL-6 的产生，IC50值为 200 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Haile, P.A., Votta, B.J., Marquis, R.W., et al.The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 kinaseJ. Med. Chem.59(10),4867-4880(2016)
