GSK2982772
Cat. No.：YN270035
| 产品名称: | GSK2982772 |
| CAS No.: | 1622848-92-3 |
| Chemical Name: | 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide |
| Synonyms: | GSK2982772,GSK-2982772,GSK 2982772 |
| 分子量: | 377.40 |
| 分子式: | C₂₀H₁₉N₅O₃ |
| SMILES: | O=C(C1=NC(CC2=CC=CC=C2)=NN1)N[C@H]3COC4=CC=CC=C4N(C)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2982772 是可口服的、有效的 ATP 竞争型的RIP1酶抑制剂，对人和猴子 RIP1 的IC50值分别为 16 nM 和 20 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
P.A., H., Berger, S.B., Jeong, J.U., et al.Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseasesJ. Med. Chem.60(4),1247-1261(2017)
