GSK2983559 free acid
Cat. No.：YN270110
CAS No. ：1579965-12-0
| 产品名称: | GSK2983559 free acid |
| CAS No.: | 1579965-12-0 |
| Chemical Name: | 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-ethanol, 1-(dihydrogen phosphate) |
| Synonyms: | RIP2 kinase inhibitor 1,RIPK2-IN-1 |
| 分子量: | 538.53 |
| 分子式: | C₂₁H₂₃N₄O₇PS₂ |
| SMILES: | CC(C)(C)S(C(C(OCCOP(O)(O)=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2983559 free acid (compound 3) 是一种高效、特异性的，口服有效的受体相互作用蛋白 2(RIP2)激酶抑制剂。GSK2983559 free acid 在体内和人类炎症性肠病外植体样本中，具有良好的阻断多种促炎细胞因子反应活性。 |
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Haile, P.A., Casillas, L.N., Votta, B.J., et al.Discovery of a first-in-class receptor interacting protein 2 (RIP2) kinase specific clinical candidate, 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate, for the treatment of inflammatory diseasesJ. Med. Chem.62(14),6482-6494(2019)
