Y-33075
Cat. No.：YN450008
CAS No. ：199433-58-4
规格
价格(RMB)
库存
| 产品名称: | Y-33075 |
| CAS No.: | 199433-58-4 |
| Chemical Name: | 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide |
| Synonyms: | Y 39983 |
| 分子量: | 280.32 |
| 分子式: | C₁₆H₁₆N₄O |
| SMILES: | O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Y-33075 是一种有效的ROCK抑制剂，源于 Y-27632，但活性更强，IC50值 3.6 nM。 |
| IC50和靶点: | [{name:"ROCK:3.6 nM (IC50)"},{name: "PKC:420 nM (IC50)"},{name: "CaMKII:810 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tokushige, H., Inatani, M., Nemoto, S., et al.Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeysInvest. Ophthalmol. Vis. Sci.48(7),3216-3222(2007)
Sagawa, H., Terasaki, H., Nakamura, M., et al.A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult catsExp. Neurol.205(1),230-240(2007)
Gao, C., Huang, L., Long, Y., et al.Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelinationNeuroimmunomodulation20(6),334-340(2013)
