Y-27632 dihydrochloride
Cat. No.：YN450025
CAS No. ：129830-38-2
规格
价格(RMB)
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| 产品名称: | Y-27632 dihydrochloride |
| CAS No.: | 129830-38-2 |
| Chemical Name: | trans-4-[(1R)-1-aminoethyl]-N-4-pyridinyl-Cyclohexanecarboxamide, dihydrochloride |
| Synonyms: | 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl |
| 分子量: | 320.26 |
| 分子式: | C₁₄H₂₃Cl₂N₃O |
| SMILES: | O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Y-27632 dihydrochloride 是口服有效的， ATP 竞争性的ROCK-I和ROCK-II抑制剂，Ki分别为 220 nM 和 300 nM。Y-27632 dihydrochloride 诱导凋亡 (apoptosis)。Y-27632 dihydrochloride 通过上皮-间充质过渡样调节引发人诱导多能干细胞 (hIPSCs) 选择性地分化为间胚层谱系。 |
| IC50和靶点: | [{name:"ROCK-I:220 nM (Ki)"},{name: "ROCK-II:300 nM (Ki)"},{name: "PKN:3.1 μM (Ki)"},{name: "Citron kinase:5.3 μM (Ki)"},{name: "PKCα:73 μM (Ki)"},{name: "PKA:25 μM (Ki)"}] |
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Davies, S.P., Reddy, H., Caivano, M., et al.Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochem. J.351(1),95-105(2000)
Uehata, M., Ishizaki, T., Satoh, H., et al.Calcium sensitization of smooth muscle mediated by a Rho-assocciated protein kinase in hypertensionNature389,990-994(1997)
Watanabe, K., Ueno, M., Kamiya, D., et al.A ROCK inhibitor permits survival of dissociated human embryonic stem cellsNat. Biotechnol.25(6),681-686(2007)
