SB-772077B dihydrochloride
Cat. No.：YN450028
CAS No. ：607373-46-6
规格
价格(RMB)
库存
| 产品名称: | SB-772077B dihydrochloride |
| CAS No.: | 607373-46-6 |
| Chemical Name: | [2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl][(3S)-3-amino-1-pyrrolidinyl]-methanone, dihydrochloride |
| Synonyms: | |
| 分子量: | 415.28 |
| 分子式: | C₁₅H₂₀Cl₂N₈O₂ |
| SMILES: | [H]Cl.O=C(C1=CN=CC2=C1N(CC)C(C3=NON=C3N)=N2)N4C[C@@H](N)CC4.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-772077B dihydrochloride 是一种基于氨基呋喃的 Rho 激酶(ROCK)抑制剂，ROCK1 和 ROCK2 的IC50值分别为 5.6 nM、6 nM。 |
| IC50和靶点: | [{name:"ROCK1:5.6 nM (IC50)"},{name: "ROCK2:6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Doe, C., Bentley, R., Behm, D.J., et al.Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activitiesJ. Pharmacol. Exp. Ther.320(1),89-98(2007)
Dhaliwal, J.S., Badejo, A.M., Jr., Casey, D.B., et al.Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitorJ. Pharmacol. Exp. Ther.330(1),334-341(2009)
