GSK429286A
Cat. No.：YN450032
CAS No. ：864082-47-3
规格
价格(RMB)
库存
| 产品名称: | GSK429286A |
| CAS No.: | 864082-47-3 |
| Chemical Name: | N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide |
| Synonyms: | RHO-15 |
| 分子量: | 432.37 |
| 分子式: | C₂₁H₁₆F₄N₄O₂ |
| SMILES: | O=C(C(C(C1=CC=C(C(F)(F)F)C=C1)C2)=C(C)NC2=O)NC3=CC4=C(NN=C4)C=C3F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK429286A是选择性的ROCK1抑制剂，IC50值为14 nM。 |
| IC50和靶点: | [{name:"ROCK1:14 nM (IC50)"},{name: "RSK:780 nM (IC50)"},{name: "p70S6K:1940 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
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| Solvent & Solubility: |
Goodman, K.B., Cui, H., Dowdell, S.E., et al.Development of dihydropyridone indazole amides as selective Rho-kinase inhibitorsJ. Med. Chem.50(1),6-9(2007)
Nichols, R.J., Dzamko, N., Hutti, J.E., et al.Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's diseaseBiochem. J.424(1),47-60(2009)
