Hydroxyfasudil hydrochloride
Cat. No.：YN450087
CAS No. ：155558-32-0
规格
价格(RMB)
库存
| 产品名称: | Hydroxyfasudil hydrochloride |
| CAS No.: | 155558-32-0 |
| Chemical Name: | 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone, monohydrochloride |
| Synonyms: | 羟基法舒地尔盐酸盐; HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride |
| 分子量: | 343.83 |
| 分子式: | C₁₄H₁₈ClN₃O₃S |
| SMILES: | O=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hydroxyfasudil hydrochloride 是一种ROCK抑制剂，可抑制ROCK1和ROCK2的活性，IC50值分别为 0.73 和 0.72 μM。 |
| IC50和靶点: | [{name:"ROCK2:0.72 μM (IC50)"},{name: "ROCK1:0.73 μM (IC50)"},{name: "PKA:37 μM (IC50)"}] |
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| Solvent & Solubility: |
Jacobs, M., Hayakawa, K., Swenson, L., et al.The structure of dimeric ROCK I reveals the mechanism for ligand selectivityJ. Biol. Chem.281(1),260-268(2006)
Nakamura, K., Nishimura, J., Hirano, K., et al.Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphataseJ. Cereb. Blood Flow Metab.21(7),876-885(2001)
Takemoto, M., Sun, J., Hiroki, J., et al.Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthaseCirculation106(1),57-62(2002)
Wolfrum, S., Dendorfer, A., Rikitake, Y., et al.Inhibition of rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protectionArterioscler. Thromb. Vasc. Biol.24(10),1842-1847(2004)
Satoh, S.i., Utsunomiya, T., Tsurui, K., et al.Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damageLife Sci.69(12),1441-1453(2001)
