JNJ-678
Cat. No.：YN250213
CAS No. ：1383450-81-4
| 产品名称: | JNJ-678 |
| CAS No.: | 1383450-81-4 |
| Chemical Name: | 3-[[5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl]methyl]-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-imidazo[4,5-c]pyridin-2-one |
| Synonyms: | JNJ-53718678 |
| 分子量: | 500.92 |
| 分子式: | C₂₁H₂₀ClF₃N₄O₃S |
| SMILES: | O=C(N1CC(F)(F)F)N(CC(N2CCCS(=O)(C)=O)=CC3=C2C=CC(Cl)=C3)C4=C1C=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-678 (JNJ-53718678) 是新型融合蛋白 (fusion protein) 抑制剂，有潜力用于呼吸道合胞病毒 (RSV)的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Vendeville, S., Tahri, A., Hu, L., et al.Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a potent and orally bioavailable fusion inhibitor of respiratory syncytial virusJ. Med. Chem.63(15),8046-8058(2020)
Roymans, D., Alnajjar, S.S., Battles, M.B., et al.Therapeutic efficacy of a respiratory syncytial virus fusion inhibitorNat. Commun.8(1),167(2017)
