RAF709
Cat. No.：YN350007
CAS No. ：1628838-42-5
| 产品名称: | RAF709 |
| CAS No.: | 1628838-42-5 |
| Chemical Name: | N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-benzamide |
| Synonyms: | RAF-709,RAF 709 |
| 分子量: | 542.55 |
| 分子式: | C₂₈H₂₉F₃N₄O₄ |
| SMILES: | O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC=CC(C(F)(F)F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RAF709 是一种有效的RAF抑制剂，抑制BRAF和CRAF，IC50分别为 0.4 nM 和 0.5 nM。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"CRAF:0.5 nM (IC50)"},{name: "Braf:0.4 nM (IC50)"}] |
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| Solvent & Solubility: |
Nishiguchi, G.A., Rico, A., Tanner, H., et al.Design and discovery of N-(2-methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancersJ. Med. Chem.60(12),4869-4881(2017)
