Regorafenib monohydrate
Cat. No.：YN350030
CAS No. ：1019206-88-2
| 产品名称: | Regorafenib monohydrate |
| CAS No.: | 1019206-88-2 |
| Chemical Name: | |
| Synonyms: | BAY 73-4506 monohydrate |
| 分子量: | 500.83 |
| 分子式: | C₂₁H₁₇ClF₄N₄O₄ |
| SMILES: | O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Regorafenib monohydrate (BAY 73-4506 monohydrate) 是一种多靶点抑制剂，对VEGFR1/2/3，PDGFRβ，Kit，RET和Raf-1的IC50分别为 13 nM，4.2 nM，46 nM，22 nM，7 nM，1.5 nM 和 2.5 nM。 |
| IC50和靶点: | [{name:"Raf-1:2.5 nM (IC50)"},{name: "Tie2:311 ± 46 nM (IC50)"},{name: "VEGFR2:4.2 nM (IC50)"},{name: "VEGFR1:13 nM (IC50)"},{name: "BRafV600E:19 nM (IC50)"},{name: "PDGFRβ:22 nM (IC50)"},{name: "Braf:28 nM (IC50)"},{name: "VEGFR3:46 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
