GW 5074
Cat. No.：YN350044
CAS No. ：220904-83-6
| 产品名称: | GW 5074 |
| CAS No.: | 220904-83-6 |
| Chemical Name: | 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one |
| Synonyms: | Raf1 Kinase Inhibitor I,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,GW5074 |
| 分子量: | 520.94 |
| 分子式: | C₁₅H₈Br₂INO₂ |
| SMILES: | O=C1NC2=C(/C1=C/C3=CC(Br)=C(C(Br)=C3)O)C=C(C=C2)I |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW 5074 是一种有效的，选择性的c-Raf抑制剂，IC50值为 9 nM；对 JNK1/2/3，MEK1，MKK6/7，CDK1/2，c-Src，p38 MAP，VEGFR2 或 c-Fms 等没有作用。 |
| IC50和靶点: | [{name:"c-Raf:9 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dhillon, A.S., and Kolch, W.Untying the regulation of the Raf-1 kinaseArch. Biochem. Biophys.404,3-9(2002)
Kunnimalaiyaan, M., and Chen, H.The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors?Anticancer Drugs17,139-142(2006)
Lackey, K., Cory, M., David, R., et al.The discovery of potent cRaf1 kinase inhibitorsBioorg. Med. Chem. Lett.10(3),223-226(2000)
