Belvarafenib
Cat. No.：YN350061
CAS No. ：1446113-23-0
| 产品名称: | Belvarafenib |
| CAS No.: | 1446113-23-0 |
| Chemical Name: | 4-amino-N-[1-[(3-chloro-2-fluorophenyl)amino]-6-methyl-5-isoquinolinyl]-thieno[3,2-d]pyrimidine-7-carboxamide |
| Synonyms: | HM95573; GDC-5573; RG6185 |
| 分子量: | 478.93 |
| 分子式: | C₂₃H₁₆ClFN₆OS |
| SMILES: | O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Belvarafenib (HM95573) 是一种有效的，广泛的迅速加速纤维肉瘤激酶(RAF)的抑制剂，其对 B-RAF，B-RAFv600E和C-RAF 的IC50值分别为 56 nM, 7 nM 和 5 nM。 |
| IC50和靶点: | [{name:"BRafV600E:7 nM (IC50)"},{name: "CRAF:5 nM (IC50)"},{name: "B-Raf:56 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Man, R.-J., Zhang, Y.-L., Jiang, A.-Q., et al.A patent review of RAF kinase inhibitors (2010-2018)Expert Opin. Ther. Pat.29(9),675-688(2019)
