SB-590885
Cat. No.：YN350062
CAS No. ：405554-55-4
| 产品名称: | SB-590885 |
| CAS No.: | 405554-55-4 |
| Chemical Name: | 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
| Synonyms: | SB590885; SB 590885 |
| 分子量: | 453.54 |
| 分子式: | C₂₇H₂₇N₅O₂ |
| SMILES: | O/N=C1CCC2=CC(C3=C(NC(C4=CC=C(C=C4)OCCN(C)C)=N3)C5=CC=NC=C5)=CC=C/12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-590885 是一种有效的B-Raf抑制剂，Ki值为 0.16 nM；对其选择性是对 c-Raf 的 11 倍多。 |
| IC50和靶点: | [{name:"B-Raf:0.16 nM (Ki)"},{name: "c-Raf:1.72 nM (Ki)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
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King, A.J., Patrick, D.R., Batorsky, R.S., et al.Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885Cancer Res.66(23),11100-11105(2006)
Klein, R.M., and Higgins, P.J.A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibitionMol. Cancer10,2-8(2011)
Ahnstedt, H., Säveland, H., Nilsson, O., et al.Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathwayBMC Neurosci.12,1-9(2011)
