LXH254
Cat. No.：YN350076
CAS No. ：1800398-38-2
| 产品名称: | LXH254 |
| CAS No.: | 1800398-38-2 |
| Chemical Name: | N-[3-[2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide |
| Synonyms: | LXH254;Naporafenib;LXH254 free base;15JL80DG6H;N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide;N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-car |
| 分子量: | 502.49 |
| 分子式: | C₂₅H₂₅F₃N₄O₄ |
| SMILES: | CC1=CC=C(NC(C2=CC(C(F)(F)F)=NC=C2)=O)C=C1C3=CC(N4CCOCC4)=NC(OCCO)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LXH254 是一种有效的B/C RAF抑制剂，详细信息请参考专利文献 WO2018051306A1 中的化合物 A。 |
| IC50和靶点: | [{name:"CRAF:0.072 nM (IC50)"},{name: "Braf:0.21 nM (IC50)"},{name: "ARAF:6.4 nM (IC50)"},{name: "p38α:2.1 μM (IC50)"},{name: "Abl1:4.9 μM (IC50)"}] |
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| Solvent & Solubility: |
Stuart, D.D., Shao, W., Mishina, Y., et al.Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitorCancer Res.78(13 Supplement),(2018)
