AZ304
Cat. No.：YN350088
CAS No. ：942507-42-8
| 产品名称: | AZ304 |
| CAS No.: | 942507-42-8 |
| Chemical Name: | |
| Synonyms: | AZ304;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;ZB1523;s8755;AK00784396;3-(2-Cyanopropan-2-yl)-N-[3-[(7-methoxyquinazolin-4-yl)amino]-4-methylphenyl]benzamide |
| 分子量: | 451.52 |
| 分子式: | C₂₇H₂₅N₅O₂ |
| SMILES: | O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ304 是一种BRAF双重抑制剂，有效抑制野生型 BRAF，突变型 BRAF (V600E) 和野生型 CRAF，IC50值分别为 79 nM，38 nM 和 68 nM。AZ304 对其他激酶有显著抑制作用，如 p38 (IC50，6 nM)，CSF1R (IC50，35 nM)。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"BRafV600E:38 nM (IC50)"},{name: "BRAFWT:79 nM (IC50)"},{name: "CRAF:68 nM (IC50)"},{name: "p38:6 nM (IC50)"},{name: "CSF1R:35 nM (IC50)"},{name: "MAP3K7:6400 nM (IC50)"},{name: "CSK:7050 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
