LY3009120
Cat. No.：YN350114
CAS No. ：1454682-72-4
| 产品名称: | LY3009120 |
| CAS No.: | 1454682-72-4 |
| Chemical Name: | N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea; |
| Synonyms: | DP-4978 |
| 分子量: | 424.51 |
| 分子式: | C₂₃H₂₉FN₆O |
| SMILES: | O=C(NC1=CC(C2=CC3=CN=C(NC)N=C3N=C2C)=C(C)C=C1F)NCCC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY3009120是泛RAF抑制剂，其抑制BRAFV600E，BRAFWT和CRAFWT的IC50分别为5.8，9.1和15 nM。 |
| IC50和靶点: | [{name:"BRafV600E:5.8 nM (IC50)"},{name: "Braf:9.1 nM (IC50)"},{name: "CRAF:15 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Henry, J. et al.: J. Med. Chem., 58, 4165 (2015)
