L-779450
Cat. No.：YN350120
CAS No. ：303727-31-3
| 产品名称: | L-779450 |
| CAS No.: | 303727-31-3 |
| Chemical Name: | 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol |
| Synonyms: | L-779,450 |
| 分子量: | 347.80 |
| 分子式: | C₂₀H₁₄ClN₃O |
| SMILES: | OC1=CC(C2=C(C3=CC=NC=C3)N=C(C4=CC=CC=C4)N2)=CC=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-779450 是一种有效的选择性B-Raf抑制剂，Kd为 2.4 nM。 |
| IC50和靶点: | [{name:"B-Raf:2.4 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Takle, A.K., Brown, M.B., Savies, S., et al.The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinaseBioorg. Med. Chem. Lett.18(15),4373-4376(2008)
Berger, A., Quast, S.A., Plötz, M., et al.RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cellsJ. Invest. Dermatol.134(2),430-440(2014)
