Regorafenib Hydrochloride
Cat. No.：YN350134
CAS No. ：835621-07-3
| 产品名称: | Regorafenib Hydrochloride |
| CAS No.: | 835621-07-3 |
| Chemical Name: | |
| Synonyms: | 瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride |
| 分子量: | 519.28 |
| 分子式: | C₂₁H₁₆Cl₂F₄N₄O₃ |
| SMILES: | ClC1=C(C(F)(F)F)C=C(NC(NC2=C(F)C=C(OC3=CC=NC(C(NC)=O)=C3)C=C2)=O)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) 是一种多靶点抑制剂，靶作用于VEGFR1/2/3，PDGFRβ，Kit，RET和Raf-1，IC50值分别为 13/4.2/46，22，7，1.5 和 2.5 nM。 |
| IC50和靶点: | [{name:"VEGFR1:13 nM (IC50)"},{name: "VEGFR2:4.2 nM (IC50)"},{name: "VEGFR3:46 nM (IC50)"},{name: "PDGFRβ:22 nM (IC50)"},{name: "Braf:28 nM (IC50)"},{name: "BRafV600E:19 nM (IC50)"},{name: "Raf-1:2.5 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
