ZM 336372
Cat. No.：YN350136
| 产品名称: | ZM 336372 |
| CAS No.: | 208260-29-1 |
| Chemical Name: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
| Synonyms: | Zinc00581684 |
| 分子量: | 389.45 |
| 分子式: | C₂₃H₂₃N₃O₃ |
| SMILES: | O=C(NC1=CC=C(C)C(NC(C2=CC=C(O)C=C2)=O)=C1)C3=CC=CC(N(C)C)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZM 336372 是一种有效的蛋白激酶c-Raf抑制剂。在含有 0.1 mM ATP 的情况下，IC50值为 0.07 μM。 |
| IC50和靶点: | [{name:"c-Raf:0.07 μM (IC50, 0.1 mM ATP)"}] |
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| Solvent & Solubility: |
Hall-Jackson, C.A., Eyers, P.A., Cohen, P., et al.Paradoxical activation of Raf by a novel Raf inhibitorChem. Biol.6(8),559-568(1999)
Van Gompel, J.J., Kunnimalaiyaan, M., Holen, K., et al.ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cellsMol. Cancer Ther.4(6),910-917(2005)
