B-Raf inhibitor 1 dihydrochloride
Cat. No.：YN350141
| 产品名称: | B-Raf inhibitor 1 dihydrochloride |
| CAS No.: | 1191385-19-9 |
| Chemical Name: | N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine, dihydrochloride |
| Synonyms: | B-Raf inhibitor 1 dihydrochloride |
| 分子量: | 551.86 |
| 分子式: | C₂₆H₂₁Cl₃N₈ |
| SMILES: | CC1=CC=C2C(C=CN=C2NC3=CC=C(Cl)C=C3)=C1NC4=NC=CC=C4C5=NC=NC6=C5N=CN6.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | B-Raf inhibitor 1 dihydrochloride 是一种有效的Raf激酶抑制剂，作用于 B-RafWT, B-RafV600E, 和 C-Raf,Ki分别为 1 nM, 1 nM, 和 0.3 nM。 |
| IC50和靶点: | [{name:"B-Raf:1 nM (Ki)"},{name: "B-RafV600E:1 nM (Ki)"},{name: "c-Raf:0.3 nM (Ki)"}] |
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Carnahan, J., Beltran, P.J., Babij, C., et al.Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growthMol. Cancer Ther.9(8),2399-2410(2010)
Smith, A.L., DeMorin, F.F., Paras, N.A., et al.Selective inhibitors of the mutant B-Raf pathway: Discovery of a potent and orally bioavailable aminoisoquinolineJ. Med. Chem.52(20),6189-6192(2009)
