Dabrafenib
Cat. No.：YN350147
CAS No. ：1195765-45-7
| 产品名称: | Dabrafenib |
| CAS No.: | 1195765-45-7 |
| Chemical Name: | N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide |
| Synonyms: | 达拉非尼; GSK2118436A; GSK2118436 |
| 分子量: | 519.56 |
| 分子式: | C₂₃H₂₀F₃N₅O₂S₂ |
| SMILES: | CC(C)(C)C1=NC(C2=C(F)C(NS(C3=C(F)C=CC=C3F)(=O)=O)=CC=C2)=C(C4=CC=NC(N)=N4)S1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dabrafenib (GSK2118436A) 是ATP竞争型的Raf抑制剂，抑制C-Raf和B-RafV600E的IC50分别为 5 nM 和 0.6 nM。 |
| IC50和靶点: | [{name:"BRafV600E:0.6 nM (IC50)"},{name: "CRAF:5 nM (IC50)"}] |
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| Solvent & Solubility: |
King, A.J., Arnone, M.R., Bleam, M.R., et al.Dabrafenib; Preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesionsPLoS One8(7),e67583(2013)
