ML786 dihydrochloride
Cat. No.：YN350153
| 产品名称: | ML786 dihydrochloride |
| CAS No.: | 1237536-18-3 |
| Chemical Name: | 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide Dihydrochloride |
| Synonyms: | |
| 分子量: | 611.48 |
| 分子式: | C₂₉H₃₁Cl₂F₃N₄O₃ |
| SMILES: | O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML786 dihydrochloride 是一种有效和具有口服活性的Raf抑制剂，对V600EΔB-Raf，wt B-Raf和C-Raf的IC50值分别为2.1，4.2 和 2.5 nM。ML786 dihydrochloride 还抑制Abl-1，DDR2，EPHA2，KDR和RET(IC50=<0.5, 7.0, 11, 6.2, 0.8 nM)。ML786 dihydrochloride 可用于癌症研究。 |
| IC50和靶点: | [{name:"RAF:2.1 nM (IC50)"},{name: "Abl1:<0.5 nM (IC50)"},{name: "DDR2:7.0 nM (IC50)"},{name: "KDR:6.2 nM (IC50)"},{name: "EPHA2:11 nM (IC50)"},{name: "RET:0.8 nM (IC50)"}] |
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| Solvent & Solubility: |
Huang, S. et al.: Bioorg. Med. Chem. Let., 26, 1156 (2016)
