Agerafenib
Cat. No.：YN350154
CAS No. ：1188910-76-0
| 产品名称: | Agerafenib |
| CAS No.: | 1188910-76-0 |
| Chemical Name: | N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-urea |
| Synonyms: | CEP-32496; RXDX-105 |
| 分子量: | 517.46 |
| 分子式: | C₂₄H₂₂F₃N₅O₅ |
| SMILES: | O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C(C=C(OC)C(OC)=C4)C4=NC=N3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Agerafenib (CEP-32496; RXDX-105) 是一种口服高效的BRAFV600E抑制剂，Kd为 14 nM。 |
| IC50和靶点: | [{name:"BRafV600E:14 nM (Kd)"},{name: "Braf:36 nM (Kd)"},{name: "CRAF:39 nM (Kd)"},{name: "c-Kit:2 nM (Kd)"},{name: "Ret:2 nM (Kd)"},{name: "LCK:2 nM (Kd)"},{name: "Abl-1:3 nM (Kd)"},{name: "VEGFR-2:8 nM (Kd)"},{name: "CSF-1R:9 nM (Kd)"},{name: "EPHA2:14 nM (Kd)"},{name: "EGFR:22 nM (Kd)"},{name: "c-Met:513 nM (Kd)"},{name: "JAK-2:4700 nM (Kd)"},{name: "MEK-1:7100 nM (Kd)"},{name: "MEK-2:8300 nM (Kd)"}] |
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Tronnier, M., and Mitteldorf, C.Treating advanced melanoma: Current insights and opportunitiesCancer Manag. Res.6,349-356(2014)
James, J., Ruggeri, B., Armstrong, R.C., et al.CEP-32496: a novel orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activityMol. Cancer Ther.11(4),930-941(2012)
