TAK-580
Cat. No.：YN350157
CAS No. ：1096708-71-2
| 产品名称: | TAK-580 |
| CAS No.: | 1096708-71-2 |
| Chemical Name: | 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide |
| Synonyms: | MLN 2480; BIIB-024 |
| 分子量: | 506.29 |
| 分子式: | C₁₇H₁₂Cl₂F₃N₇O₂S |
| SMILES: | NC1=NC=NC(C(N[C@@H](C2=NC=C(C(NC3=NC=C(Cl)C(C(F)(F)F)=C3)=O)S2)C)=O)=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAK-580 (MLN 2480) 是一种可口服的，具有选择性的广谱的Raf抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Whittaker, S.R., Cowley, G.S., Wagner, S., et al.Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitorsMol. Cancer Ther.14(12),2700-2711(2015)
Rasco, D.W., Olszanski, A.J., Patnaik, A., et al.MLN2480, an investigational oral pan-RAF kinase inhibitor, in patients (pts) with relapsed or refractory solid tumors: Phase I studyJ. Clin. Oncol.31(suppl 15),(2013)
Cunniff, E.G.C., Zhang, J., Chouitar, J., et al.Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRCJ. Clin. Oncol.31(15 Suppl),(2013)
