Encorafenib
Cat. No.：YN350163
CAS No. ：1269440-17-6
| 产品名称: | Encorafenib |
| CAS No.: | 1269440-17-6 |
| Chemical Name: | N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-carbamic acid, methyl ester |
| Synonyms: | LGX818 |
| 分子量: | 540.01 |
| 分子式: | C₂₂H₂₇ClFN₇O₄S |
| SMILES: | O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Encorafenib (LGX818) 是一种高效的BRAF抑制剂，对 BRAFV600E细胞有选择性抗增殖和促凋亡活性，EC50值为 4 nM。 |
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Tronnier, M., and Mitteldorf, C.Treating advanced melanoma: Current insights and opportunitiesCancer Manag. Res.6,349-356(2014)
Stuart, D.D., Li, N., Poon, D.J., et al.Preclinical profile of LGX818: A potent and selective RAF kinase inhibitorCancer Res.72,(2012)
Huang, T., Karsy, M., Zhuge, J., et al.B-Raf and the inhibitors: From bench to bedsideJ. Hematol. Oncol.6,1-9(2013)
