PLX7904
Cat. No.：YN350195
CAS No. ：1393465-84-3
| 产品名称: | PLX7904 |
| CAS No.: | 1393465-84-3 |
| Chemical Name: | N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-sulfamide |
| Synonyms: | PB04 |
| 分子量: | 512.53 |
| 分子式: | C₂₄H₂₂F₂N₆O₃S |
| SMILES: | O=S(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CN=C(C5CC5)N=C4)C=C32)=O)=C1F)(N(CC)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PLX7904 是有效的，选择性的BRAF抑制剂，在表达突变体 RAS 的细胞中，对 BRAFV600E的IC50值约为 5 nM。 |
| IC50和靶点: | [{name:"BRafV600E:5 nM (IC50, in mutant RAS expressing cells)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, C., Spevak, W., Zhang, Y., et al.RAF inhibitors that evade paradoxical MAPK pathway activationNature526(7574),583-586(2015)
