PPTN hydrochloride
Cat. No.：YN322377
CAS No. ：1992047-65-0
| 产品名称: | PPTN hydrochloride |
| CAS No.: | 1992047-65-0 |
| Chemical Name: | 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride |
| Synonyms: | |
| 分子量: | 511.9622496 |
| 分子式: | C29H24F3NO2 • HCl |
| SMILES: | O=C(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PPTN hydrochloride 是一种有效，高亲和力，竞争性和高选择性的P2Y14受体拮抗剂，KB为 434 pM。PPTN hydrochloride 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和抗免疫活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Barrett, M.O., Sesma, J.I., Ball, C.B., et al.A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophilsMol. Pharmacol.84(1),41-49(2013)
Lin, J., Liu, F., Zhang, Y.-Y., et al.P2Y14 receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretionJ. Cell. Physiol.234(11),21199-21210(2019)
Lin, J., Zhang, Y.-Y., Liu, F., et al.The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory painNeurochem Int.131,104567(2019)
