BI-D1870
Cat. No.：YN350042
| 产品名称: | BI-D1870 |
| CAS No.: | 501437-28-1 |
| Chemical Name: | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridinone |
| Synonyms: | 2-((3,5-Difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one;BI-D1870;2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one;2-[(3,5-DIFLUORO-4-HYDROXYPHENYL)AMINO]-7,8-DIHYDRO-5,7-DIMETHYL-8-( |
| 分子量: | 391.42 |
| 分子式: | C₁₉H₂₃F₂N₅O₂ |
| SMILES: | OC1=C(F)C=C(NC2=NC(N(CCC(C)C)C(C)C(N3C)=O)=C3C=N2)C=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BI-D1870 是ATP 竞争性的，细胞可渗透性的RSK抑制剂，抑制 RSK1、RSK2、RSK3、RSK4 的IC50值分别为 31 nM、24 nM、18 nM、15 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Romeo, Y., Zhang, X., and Roux, P.P.Regulation and function of the RSK family of protein kinasesBiochem. J.441(2),553-569(2012)
Sapkota, G.P., Cummings, L., Newell, F.S., et al.BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivoBiochem. J.401(1),29-38(2007)
Bain, J., Plater, L., Elliot, M., et al.The selectivity of protein kinase inhibitors: A further updateBiochem. J.408(3),297-315(2007)
