BRD7389
Cat. No.：YN350104
| 产品名称: | BRD7389 |
| CAS No.: | 376382-11-5 |
| Chemical Name: | 1-[(2-phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| Synonyms: | BRD7389 |
| 分子量: | 366.41 |
| 分子式: | C₂₄H₁₈N₂O₂ |
| SMILES: | O=C(C(C=CC=C1)=C1C2=C(NCCC3=CC=CC=C3)C(N4)=O)C5=C2C4=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD7389 是一种特异性的RSK家族激酶抑制剂，对RSK1，RSK2和RSK3的IC50分别为 1.5 μM，2.4 μM 和 1.2 μM。BRD7389 可以诱导胰腺 α 细胞中胰岛素表达。 |
| IC50和靶点: | [{name:"RSK1:1.5 μM (IC50)"},{name: "RSK2:2.4 μM (IC50)"},{name: "RSK3:1.2 μM (IC50)"},{name: "CDK5/p35:6.5 μM (IC50)"},{name: "DRAK1:2.8 μM (IC50)"},{name: "FLT3:3.5 μM (IC50)"},{name: "PIM1:3.7 μM (IC50)"},{name: "PKG1α:6.5 μM (IC50)"},{name: "SGK:13.8 μM (IC50)"}] |
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Fomina-Yadlin, D., Kubicek, S., Walpita, D., et al.Small-molecule inducers of insulin expression in pancreatic α-cellsProc. Natl. Acad. Sci. USA107(34),15099-15104(2010)
