LY-2584702 tosylate salt
Cat. No.：YN350112
CAS No. ：1082949-68-5
| 产品名称: | LY-2584702 tosylate salt |
| CAS No.: | 1082949-68-5 |
| Chemical Name: | 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine, 4-methylbenzenesulfonate |
| Synonyms: | LY2584702 tosylate |
| 分子量: | 617.62 |
| 分子式: | C₂₈H₂₇F₄N₇O₃S |
| SMILES: | CN1C=C(C2=CC=C(F)C(C(F)(F)F)=C2)N=C1C3CCN(C4=C5C(NN=C5)=NC=N4)CC3.O=S(C6=CC=C(C)C=C6)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY-2584702 tosylate salt 是一种 ATP 竞争性的选择性p70S6K抑制剂，IC50为 4 nM。LY-2584702 抑制S6K1的IC50为 2 nM。 |
| IC50和靶点: | [{name:"p70S6K:4 nM (IC50)"}] |
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| Solvent & Solubility: |
Tolcher, A., Goldman, J., Patnaik, A., et al.A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumoursEur. J. Cancer50(5),867-875(2014)
Roberts, J.L., He, B., Erickson, A., et al.Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cellsBiochim. Biophys. Acta1861(3),166-176(2016)
Gu, X., Fu, X., Lu, J., et al.Pharmacological inhibition of S6K1 impairs self-renewal and osteogenic differentiation of bone marrow stromal cellsJ. Cell. Biochem.119(1),1041-1049(2017)
