CKI-7 free base
Cat. No.：YN350133
CAS No. ：120615-25-0
| 产品名称: | CKI-7 free base |
| CAS No.: | 120615-25-0 |
| Chemical Name: | N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide; CKI-7; |
| Synonyms: | CKI-7 |
| 分子量: | 285.75 |
| 分子式: | C₁₁H₁₂ClN₃O₂S |
| SMILES: | O=S(C1=CC=C(Cl)C2=C1C=NC=C2)(NCCN)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CKI-7 free base 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC50为 6 μM，Ki为 8.5 μM。CKI-7 free base 选择性抑制Cdc7激酶，还抑制SGK，S6K1以及MSK1。CKI-7 free base 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。 |
| IC50和靶点: | [{name:"CK1:6 μM (IC50)"},{name: "CK1:8.5 μM (Ki)'}, 'Cdc7', 'SGK', 'MSK1'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hidaka, H., et al.: J. Biol. Chem., 264, 9, 4924 (1989)
