GSK-25
Cat. No.：YN350144
CAS No. ：874119-56-9
| 产品名称: | GSK-25 |
| CAS No.: | 874119-56-9 |
| Chemical Name: | |
| Synonyms: | GSK25 |
| 分子量: | 513.33 |
| 分子式: | C₂₄H₁₆Cl₂F₂N₆O |
| SMILES: | ClC1=CC(C2=NC(C3=C(F)C=C(Cl)C=C3)C(C(NC4=C(F)C=C(NN=C5)C5=C4)=O)=C(C)N2)=CC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-25 是一种有效的、选择性的，具有口服活性的ROCK1抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50分别为2.5、5.2、2.5 μM)。 |
| IC50和靶点: | [{name:"ROCK1:7 nM (IC50)"},{name: "RSK1:398 nM (IC50)"},{name: "p70S6K:1000 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
