SL 0101-1
Cat. No.：YN350156
| 产品名称: | SL 0101-1 |
| CAS No.: | 77307-50-7 |
| Chemical Name: | 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Synonyms: | SL0101 |
| 分子量: | 516.45 |
| 分子式: | C₂₅H₂₄O₁₂ |
| SMILES: | OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SL 0101-1 (SL0101) 是从热带植物F. refracta中提取得到的山萘酚糖苷，是能穿透细胞的、选择性的、可逆的、ATP竞争性的p90核糖体S6激酶(RSK)的抑制剂，其IC50值为 89 nM。SL 0101-1 (SL0101) 是选择性的RSK1/2抑制剂，其 Ki值为 1 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Smith, J.A., Poteet-Smith, C.E., Xu, Y., et al.Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferationCancer Res.65(3),1027-1034(2005)
Godeny, M.D., and Sayeski, P.P.ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1Am. J. Physiol. Cell Physiol.291,C1308-C1317(2006)
