PF-4708671
Cat. No.：YN350169
CAS No. ：1255517-76-0
| 产品名称: | PF-4708671 |
| CAS No.: | 1255517-76-0 |
| Chemical Name: | 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole |
| Synonyms: | PF4708671 |
| 分子量: | 390.41 |
| 分子式: | C₁₉H₂₁F₃N₆ |
| SMILES: | FC(C1=CC=C2N=C(CN3CCN(C4=NC=NC=C4CC)CC3)NC2=C1)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-4708671 是一种有效的细胞渗透性S6K1抑制剂，Ki为 20 nM，IC50为 160 nM。 |
| IC50和靶点: | [{name:"S6K1:160 nM (IC50)"},{name: "S6K1:20 nM (Ki)"},{name: "S6K2:65 μM (IC50)"}] |
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| Solvent & Solubility: |
Pearce, L.R., Alton, G.R., Richter, D.T., et al.Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)Biochem. J.431,245-255(2010)
Rajan, M.R., Fagerholm, S., Jönsson, C., et al.Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinasePLoS One8(4),(2013)
McNamara, C.R., Ahuja, R., Osafo-Addo, A.D., et al.Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosisPLoS One8(3),(2013)
