AT13148
Cat. No.：YN350175
CAS No. ：1056901-62-2
| 产品名称: | AT13148 |
| CAS No.: | 1056901-62-2 |
| Chemical Name: | (αS)-α-(aminomethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-benzenemethanol |
| Synonyms: | AT13148;(1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol;AT-13148;(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethanol;(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol;(alphaS)-alpha-(Aminomethyl)- |
| 分子量: | 313.78 |
| 分子式: | C₁₇H₁₆ClN₃O |
| SMILES: | ClC1=CC=C([C@](C2=CC=C(C3=CNN=C3)C=C2)(O)CN)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT13148 是一种可口服的，ATP 竞争性的AGC kinase的抑制剂，能够抑制 Akt1/Akt2/Akt3，p70S6K，PKA 和 ROCKI/ROCKII 的活性，IC50值分别为 38 nM/402 nM/50 nM，8 nM，3 nM 和 6 nM/4 nM。 |
| IC50和靶点: | [{name:"Akt1:38 nM (IC50)"},{name: "p70S6K:8 nM (IC50)"},{name: "Akt3:50 nM (IC50)"},{name: "Akt2:402 nM (IC50)"},{name: "PKA:3 nM (IC50)"},{name: "ROCKII:4 nM (IC50)"},{name: "ROCKI:6 nM (IC50)"},{name: "SGK3:63 nM (IC50)"},{name: "RSK1:85 nM (IC50)"},{name: "CHK2:860 nM (IC50)"},{name: "Aurora B:1840 nM (IC50)"}] |
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| Solvent & Solubility: |
Yap, T.A., Walton, M.I., Grimshaw, K.M., et al.AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activityClin. Cancer Res.18(14),3912-3923(2012)
Sadok, A., McCarthy, A., Caldwell, J., et al.Rho kinase inhibitors block melanoma cell migration and inhibit metastasisCancer Res.75(11),2272-2284(2015)
