BIX 02565
Cat. No.：YN350176
| 产品名称: | BIX 02565 |
| CAS No.: | 1311367-27-7 |
| Chemical Name: | (5R)-N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide |
| Synonyms: | BIX-02565;BIX02565 |
| 分子量: | 458.56 |
| 分子式: | C₂₆H₃₀N₆O₂ |
| SMILES: | O=C(C1=CC2=C(C=C1)C=C3N2[C@H](C)CCNC3=O)NC4=NC5=CC=CC=C5N4CCCN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIX 02565 是一种有效的核糖体 S6 激酶 2 (RSK2) 抑制剂，IC50为 1.1 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kirrane, T.M., Boyer, S.J., Burke, J., et al.Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivityBioorg. Med. Chem. Lett.22(1),738-742(2012)
Fryer, R.M., Muthukumarana, A., Chen, R.R., et al.Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitorsJ. Pharmacol. Exp. Ther.340(3),492-500(2012)
