FMK
Cat. No.：YN350215
| 产品名称: | FMK |
| CAS No.: | 821794-92-7 |
| Chemical Name: | 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-ethanone |
| Synonyms: | RSK2 kinase inhibitor) |
| 分子量: | 342.37 |
| 分子式: | C₁₈H₁₉FN₄O₂ |
| SMILES: | FCC(C1=C(C2=C(N=CN=C2N1CCCO)N)C3=CC=C(C=C3)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FMK 是一种不可逆的RSK2抑制剂，能够共价修饰 RSK 的 C 末端区域。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Cohen, M.S., Zhang, C., Shokat, K.M., et al.Structural bioinformatics-based design of selective, irreversible kinase inhibitorsScience308(5726),1318-1321(2005)
Kang, S., Elf, S., Lythgoe, K., et al.p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cellsJ. Clin. Invest.120(4),1165-1177(2010)
Kang, S., Dong, S., Gu, T.-L., et al.FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathwayCancer Cell12(3),201-214(2007)
