Carnosol
Cat. No.：YN350231
| 产品名称: | Carnosol |
| CAS No.: | 5957-80-2 |
| Chemical Name: | 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one |
| Synonyms: | 鼠尾草酚 |
| 分子量: | 330.42 |
| 分子式: | C₂₀H₂₆O₄ |
| SMILES: | O=C1O[C@]2([H])C3=C(C(O)=C(O)C(C(C)C)=C3)[C@@]41CCCC(C)(C)[C@]4([H])C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carnosol 是一种有效的核糖体S6激酶(RSK2)抑制剂，可用于胃癌相关研究，其IC50值约为 5.5 μM。Carnosol 是一种Nrf2激活剂，增加 Nrf2 的水平以及能促进血红素氧合酶 1 (HMOX1) 的表达。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chan, M.M., Ho, C.T., and Huang, H.I.Effects of three dietary phytochemicals from tea, rosemary, and turmeric on inflammation-induced nitrite productionCancer Lett.96(1),23-29(1995)
Aruoma, O.I., Halliwell, B., Aeschbach, R., et al.Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acidXenobiotica22(2),257-268(1992)
Poeckel, D., Greiner, C., Verhoff, M., et al.Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytesBiochem. Pharmacol.76(1),91-97(2008)
Singletary, K., MacDonald, C., and Wallig, M.Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formationCancer Lett.104(1),43-48(1996)
