CKI-7
Cat. No.：YN350273
| 产品名称: | CKI-7 |
| CAS No.: | 1177141-67-1 |
| Chemical Name: | N-(2-aminoethyl)-5-chloro-8-isoquinolinesulfonamide, dihydrochloride |
| Synonyms: | CKI-7 2HCl,CKI7 2HCl,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI 7 2HCl,CKI7 dihydrochloride,CKI 7 dihydrochloride,CKI-7 dihydrochloride |
| 分子量: | 358.67 |
| 分子式: | C₁₁H₁₄Cl₃N₃O₂S |
| SMILES: | O=S(C1=CC=C(Cl)C2=C1C=NC=C2)(NCCN)=O.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC50为 6 μM，Ki为 8.5 μM。CKI-7 选择性抑制Cdc7激酶，还抑制SGK，S6K1以及MSK1。CKI-7 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。 |
| IC50和靶点: | [{name:"CK1:6 μM (IC50)"},{name: "CK1:8.5 μM (Ki)'}, 'Cdc7', 'SGK', 'MSK1'] |
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| Solvent & Solubility: |
Chijiwa, T., Hagiwara, M., and Hidaka, H.A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testisJ. Biol. Chem.264(9),4924-4927(1989)
Rachidi, N., Taly, J.F., Durieu, E., et al.Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infectionAntimicrob. Agents Chemother.58(3),1501-1515(2014)
