GS-441524
Cat. No.：YN250093
CAS No. ：1191237-69-0
| 产品名称: | GS-441524 |
| CAS No.: | 1191237-69-0 |
| Chemical Name: | 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile |
| Synonyms: | GS 441524 triphosphate |
| 分子量: | 291.26 |
| 分子式: | C₁₂H₁₃N₅O₄ |
| SMILES: | N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@H](CO)[C@@H](O)[C@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GS-441524 是 Remdesivir 的主要活性代谢物，活性更优于 Remdesivir ，感染冠状病毒的原代人肺和猫细胞的细胞模型中显示出相似的活性。 GS-441524 对猫传染性腹膜炎病毒(FIPV)有较强的抑制作用，对应的EC50值为 0.78 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Agostini, M.L., Andres, E.L., Sims, A.C., et al.Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonucleasemBio9(2),e00221-00218(2018)
Pruijssers, A.J., George, A.S., Schäfer, A., et al.Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in miceCell Rep.32(3),107940(2020)
Cho, A., Saunders, O.L., Butler, T., et al.Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosidesBioorg. Med. Chem.22(8),2705-2707(2012)
